About HCG (Human Chorionic Gonadotropin) Peptide

HCG is a glycoprotein hormone made of two subunits. The alpha subunit (92 amino acids) is shared with LH, FSH and TSH. The beta subunit (145 amino acids) is unique to hCG and gives it its biological specificity. Both subunits are heavily glycosylated, and together they bind the LH/hCG receptor (LHCGR).

WHAT THE RESEARCH SHOWS

Human Chorionic Gonadotropin (hCG) is a naturally occurring peptide/glycoprotein hormone produced during pregnancy. In medical and clinical research, however, it is best known as an exogenous Luteinizing Hormone (LH) analogue. Because hCG shares an identical alpha subunit with LH (and has a substantially longer half-life), it binds directly to the body's LH receptors. Here is what decades of clinical research show:
* Preservation of Intratesticular Testosterone (ITT) on TRT: * When men take exogenous testosterone or anabolic steroids, the hypothalamic-pituitary-gonadal (HPG) axis shuts down, dropping LH levels to zero. This leads to testicular atrophy (shrinkage) and loss of fertility.
* Robust clinical trials demonstrate that low-dose hCG directly stimulates Leydig cells in the testes, maintaining normal intratesticular testosterone levels and preventing testicular atrophy, even while on full hormone replacement.
* Male Fertility & Spermatogenesis Induction:
* Landmark endocrine studies show that hCG alone (or paired with FSH) can successfully restore or maintain spermatogenesis and sperm count in men with secondary hypogonadism, making it the clinical gold standard for fertility preservation. * Upstream Neurosteroid Production:
* LH signaling does not just produce testosterone; it activates the StAR protein to convert cholesterol into pregnenolone—the "mother hormone." Research shows hCG restores downstream pathways for neurosteroids, DHEA, and progesterone that often get depleted when the HPG axis is suppressed.
* Female Ovulation Induction:
* In reproductive medicine, hCG is FDA-approved and extensively studied as a "trigger shot." Its intense LH-like surge causes the final maturation and release of an egg (ovulation) during fertility treatments and IVF protocols. 

STUDIES - All links

• Lee & Ramasamy – hCG for infertility in hypogonadal men (TAU)
• hCG in men with hypogonadism – review (PMC)
• Testosterone vs hCG in hypogonadotropic hypogonadism (DOAJ)
• Superpower – hCG guide
• Superpower – hCG guide
• Superpower – hCG medications guide
• Bolt Pharmacy – hCG treatment, UK

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