About 5-Amino-1MQ - Metabolism Body Composition Peptide

5-Amino-1MQ works by blocking the NNMT enzyme, which ramps up cellular metabolism, preserves NAD+ levels, and helps burn fat while preserving lean muscle. It is great for body recomposition.

WHAT THE RESEARCH SHOWS

Research on 5-Amino-1MQ primarily centers on its role as an NNMT inhibitor (nicotinamide N-methyltransferase), an enzyme heavily expressed in fat tissue that slows down metabolism. Here is what the preclinical studies (mostly out of the University of Texas Medical Branch) show: Targeted Fat Loss Without Dieting: In rodent studies, blocking NNMT reduced white fat cell size and led to roughly a 7% drop in body weight over 10 days notably without* changing calorie intake or suppressing appetite.
* Boosts Cellular Energy & NAD+: Inhibiting NNMT prevents the waste of NAD+, ramping up mitochondrial metabolism and making fat cells burn more fuel.
* Muscle Preservation: Research shows it can stimulate muscle stem cells (satellite cells), helping preserve or potentially repair muscle tissue while cutting fat.
* Cardiometabolic Markers: Studies noted lower total cholesterol and improved insulin sensitivity.

Studies

Dimet-Wiley et al., 2024 – NNMT inhibition mimics and boosts exercise effects in aged mice (Scientific Reports). The inhibitor alone raised grip strength by 40% in sedentary aged mice. Combined with exercise, the improvement reached 60%. PubMed - link
Neelakantan et al., 2018 – NNMT inhibitors reverse diet-induced obesity in mice (Biochemical Pharmacology). This is the foundational paper. Obese mice on a high-fat diet treated systemically with the inhibitor lost body weight and white fat mass, had smaller fat cells, and had lower plasma total cholesterol. Over 11 days, untreated mice gained about 1.4% body weight while treated mice lost about 5.1%. Full text (PMC)- link
2024 follow-up – body composition, fatty liver and pharmacokinetics. This study looked at body composition, metabolic markers and fatty liver changes in obese mice, and measured how the compound distributes in the body. The authors say it supports NNMT inhibition as a way to improve obesity-related metabolic and liver problems. Full text (PMC) - link

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